Over the past few months I’ve been trying to work with the HCSConnect web service API that Cellomics provides as a means to programmatically access the Arrayscan image and data store. While the API works for getting things such as plate names, I was unable to retrieve images. After much poking and some suggestions from […]
High Content Screens and Multivariate Z’
While contributing to a book chapter on high content screening I came across the problem of characterizing screen quality. In a traditional assay development scenario the Z factor (or Z’) is used as one of the measures of assay performance (using the positive and negative control samples). The definition of Z’ is based on a […]
Accessing High Content Data from R
Over the last few months I’ve been getting involved in the informatics & data mining aspects of high content screening. While I haven’t gotten into image analysis itself (there’s a ton of good code and tools already out there), I’ve been focusing on managing image data and meta-data and asking interesting questions of the voluminuous, […]
Call for Papers: High Content Screening: Exploring Relationships Between Small Molecules and Phenotypic Results
242nd ACS National Meeting Denver, Aug 28 – Sept 1, 2011 CINF Division Dear Colleagues, we are organizing an ACS symposium, focusing on the use of High Content Screening (HCS) for small molecule applications. High content screens, while resource intensive, are capable of providing a detailed view of the phenotypic effects of small molecules. Traditional […]
Lots of Pretty Pictures
Yesterday I attended the High Content Analysis conference in San Francisco. Over the last few months I’ve been increasingly involved in the analysis of high content screens, both for small molecules and siRNA. This conference gave me the opportunity to meet people working in the field as well as present some of our recent work […]