So much to do, so little time

Trying to squeeze sense out of chemical data

Archive for the ‘gleevec’ tag

Kinase Inhibitors and Polypharmacology

without comments

The Curious Wavefunction has a nice post on the issue of selective and non-selective kinase inhibitors. An interesting commentary, especially in the light of the recent paper on network polypharmcology. While there have been a number of papers on polypharmcology and the idea itself is very attractive, it has seemed to me that for this approach to succeed we need very detailed information on the targets and systems involved in these networks. Indeed, a current project of mine is currently hitting this problem. As Ashutosh notes,

… in the first place we don’t even know what specific subset of kinases to hit for treating a particular disease. First comes target validation, then modulation.

Written by Rajarshi Guha

November 5th, 2008 at 11:18 pm