242nd ACS National Meeting
Denver, Aug 28 – Sept 1, 2011
CINF Division
Dear Colleagues, we are organizing an ACS symposium, focusing on the use of High Content Screening (HCS) for small molecule applications. High content screens, while resource intensive, are capable of providing a detailed view of the phenotypic effects of small molecules. Traditional reporter based screens are characterized by a one-dimensional signal. In contrast, high content screens generate rich, multi-dimensional datasets that allow for wide-ranging and in-depth analysis of various aspects of chemical biology including mechanisms of action, target identification and so on. Recent developments in high-throughput HCS pose significant challenges throughout the screening pipeline ranging from assay design and miniaturization to data management and analysis. Underlying all of this is the desire to connect chemical structure to phenotypic effects.
We invite you to submit contributions highlighting novel work and new developments in High Content Screening (HCS), High Content Analysis (HCA), and data exploration as it relates to the field of small molecules. Topics of interest include but are not limited to
- Compound & in silico screening for drug discovery
- Compound profiling by high content analysis
- Chemistry & probes in imaging
- Lead discovery strategies – one size fits all or horses for courses?
- Application of HCA in discovering toxicology screening strategies
- Novel data mining approaches for HCS data that link phenotypes to chemical structures
- Software & informatics for HCS data management and integration
Tim Moran
Accelrys
tmoran@accelrys.com
+1 858 799 5609
Rajarshi Guha
NIH Chemical Genomics Center
guhar@mail.nih.gov
+1 814 404 5449