Call for Papers: High Content Screening: Exploring Relationships Between Small Molecules and Phenotypic Results

242nd ACS National Meeting Denver, Aug 28 – Sept 1, 2011 CINF Division Dear Colleagues, we are organizing an ACS symposium, focusing on the use of High Content Screening (HCS) for small molecule applications. High content screens, while resource intensive, are capable of providing a detailed view of the phenotypic effects of small molecules. Traditional […]

Drug-Target Networks & Polypharmacology

I came across Takigawa et al where they address polypharmacology by investigating drug-target pairs.  Their approach is to simultaneously identify substructures from the ligand and subsequences from the target and combine this information to suggest drug-target pairs that represent some form of polypharmacology.  More specifically their hypothesis is that “polypharmacological principles” are embedded in a […]