Some time back, John Van Drie and myself had done some work on characterizing structure-activity cliffs, which are molecules that have very similar structures but very different activities. The term originated from Maggiora, who suggested that this was a reason for the failure of many QSAR models. At the same time, such cliffs can represent […]
Hit Selection Methods for RNAi Screens
Over the last few weeks I’ve been getting up to speed on RNAi screening (see Lord et al for a nice overview) and one of the key features in this approach is to reliably select hits for followup. In many ways it is similar to hit selection in small molecule HTS but also employs techniques […]
R and Oracle
It’s been a while since my last post, but I’m getting up to speed at work. It’s been less than a month, but there’s already a ton of cool stuff going on. One of the first things I’ve been getting to grips with is the data infrastructure at the NCGC, which is based around Oracle. […]