Call for Papers (ACS Fall Meeting 2018)

The More the Merrier: Combine Drugs Together 256th ACS National Meeting Boston, August 19-23, 2018 CINF Division Dear Colleagues, we are organizing a symposium at the Fall ACS meeting in Boston focusing on computational, experimental and hybrid approaches to investigate the effect of drugs combinations on biological systems and characterizing phenomena such as synergy and […]

Call for Papers (ACS Fall Meeting 2018)

Move Away from the Lamp Post & Find Druggable Targets 256th ACS National Meeting Boston August 19-23, 2018 CINF Division Dear colleagues, we are organizing a symposium focusing on methodologies and case studies that have explored under- or unstudied targets, with the goal of elucidating their function or role in the context of human disease. […]

Post-doc (Molecular Informatics) Opening at NCATS

I have a post-doc opening in the Informatics group at NCATS, to work on computational aspects of high throughput combination screening – topics will include predicting drug combination response, visualizing large combination screens (> 5000 combinations) and so on. The NCATS combination screening platform thas tested more than 65,000 compound combinations (in checkerboard style which […]

Thoughts on the DREAM Synergy Prediction Challenge

The DREAM consortium has run a number of predictive modeling challenges and the latest one on predicting small molecule synergies has just been published. The dataset that was provided included baseline gene expression of the cell line (OCI-LY3), expression in presence of compound (2 concentrations, 2 time points), dose response data for 14 compounds and […]

Exploring medical case studies

I recently came across from BMC, a collection of more than 29,000 peer-reviewed case studies collected from a variety of journals. I’ve been increasingly interested in the possibilities of mining clinical data (inspired by impressive work from Atul Butte, Nigam Shah and others), so this seemed like a great resource to explore The folks […]